Gene Loss

Publication Details

Identifier: JB_K1AU2S

Curator: M. Lopes-Marques

DOI: 10.1016/j.celrep.2014.12.008

PMID: 25565328

Title:

Insights into the evolution of longevity from the bowhead whale genome.

Abstract:

The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.

Last update:

30-08-2024

Associated Glosses (16 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_5ULHOR	Balaena mysticetus	PRSS33	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_C2GZ4U	Balaena mysticetus	F7	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_CGOTNS	Balaena mysticetus	TMPRSS11F	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_CXRPKF	Balaena mysticetus	F12	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_EKBCSB	Balaena mysticetus	TMPRSS11B	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_EZI21C	Balaena mysticetus	KLKB1	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_I0WN9Q	Balaena mysticetus	KLK4	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_KKFAPI	Balaena mysticetus	CPO	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_MQPVWW	Balaena mysticetus	CAPN12	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_OTZUKH	Balaena mysticetus	MMP20	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008