Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| CAPN12 calpain 12 | Homo sapiens | 22 | protein-coding | CAPN15 , CAPN10 , CAPN6 , CAPN5 , CAPN13 , CAPN14 , CAPN1 , CAPN9 , CAPN3 , CAPN8 , CAPN2 , CAPN11 | 608839 |
Summary
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
GeneOntology
Gene Loss events - CAPN12 (2 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_MQPVWW | Balaena mysticetus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.celrep.2014.12.008 |
| GL_SV5NHR | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/gbe/evx187 |