Ψ F12 - Balaena mysticetus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_CXRPKF | Balaena mysticetus | LOF (frameshift, premature stop, ss) | Full | No | Genomic & Transcriptomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "In humans, a deficiency in F12 causes alterations in the coagulation process." | 10.1016/j.celrep.2014.12.008 |
| Mutation Description | "In the case of the whales, early stop codons suggest that the protein is not produced." | 10.1016/j.celrep.2014.12.008 |
| Other | "Multiple coagulation factors, most of them from the S01 family of serine proteases, have been lost in bowhead and minke whales. One of these proteases, F12, has also been inactivated in dolphins (Supplemental Data File 1), and therefore its loss probably occurred at an early stage of adaptation to the aquatic medium." | 10.1016/j.celrep.2014.12.008 |
Curator Observations
See supplementary material for details