Gene Loss

Publication Details

Identifier: JB_K1AU2S

Curator: M. Lopes-Marques

DOI: 10.1016/j.celrep.2014.12.008

PMID: 25565328

Title:

Insights into the evolution of longevity from the bowhead whale genome.

Abstract:

The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.

Last update:

30-08-2024

Associated Glosses (16 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_PRVC5R	Balaena mysticetus	PRSS48	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_RZD9M5	Balaena mysticetus	CPA3	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_UZU1GY	Balaena mysticetus	KLK7	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_VNHMXM	Balaena mysticetus	CASP12	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_WAXGFV	Balaena mysticetus	KLK8	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_XJYVCM	Balaena mysticetus	CPA2	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008