| Functional |
"Interestingly, two of the lost kallikreins, KLK7 and KLK8, have been implicated in skin homeostasis and are also absent in dolphins." |
10.1016/j.celrep.2014.12.008 |
| Functional |
"In fact, KLK8 has been directly related to terminal differentiation and desquamation of the stratum corneum, the outmost layer of the skin in mammals." |
10.1016/j.celrep.2014.12.008 |
| Mutation Description |
"While bowhead and minke whales show conserved premature stop codons in the predicted sequence of these genes (KLK7 and KLK8), dolphins display premature stop codons at different positions, suggesting a case of converging molecular evolution." |
10.1016/j.celrep.2014.12.008 |
| Phenotypic |
"The specific loss of two genes through independent mechanisms strongly suggests that this is an important evolutionary event, which could be related to the adaptation of the mammalian skin to aquatic environments." |
10.1016/j.celrep.2014.12.008 |