Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CPA3 carboxypeptidase A3	MC-CPA	Homo sapiens	11	protein-coding	CPO , CPO , CPA6 , CPA6 , CPB1 , CPB2 , CPA5 , CPA1 , CPA4 , CPA2 , CPB1 , CPB2 , CPA5 , CPA1 , CPA4 , CPO , CPO , CPA6 , CPA6 , CPA3 , CPA3 , CPA3 , CPA3 , CPA3 , CPA3 , CPB1 , CPB2 , CPA5 , CPA1 , CPA2	3.4.17.1	114851

Summary

This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004181	enables metallocarboxypeptidase activity	EXP

Component (6)

Go ID	Value	Evidence
0062023	located_in collagen-containing extracellular matrix	HDA
0005576	located_in extracellular region	HDA
0005576	located_in extracellular region	TAS
0005615	is_active_in extracellular space	IBA
0030141	located_in secretory granule	NAS
0030133	located_in transport vesicle	IEA

Process (3)

Go ID	Value	Evidence
0002003	involved_in angiotensin maturation	TAS
0006508	involved_in proteolysis	IBA
0006508	involved_in proteolysis	TAS

Gene Loss events - CPA3 (2 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_RZD9M5	Balaena mysticetus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.celrep.2014.12.008
GL_VLG4OO	Physeter catodon	Artiodactyla	Other	Full	No	10.1093/gbe/evx187