| Mutation Description |
"Several paralogues of carboxypeptidase A from the M14 family of metalloproteases have been pseudogenized in bowhead and minke whales. Thus, CPA2 and CPA3 show premature stop codons in bowhead whale (Supplemental Data File 1)." |
10.1016/j.celrep.2014.12.008 |
| Timing of Loss |
"Most of these stop codons are conserved in the genome of the minke whale. However, the overall sequence of the predicted proteins is well conserved, which suggests that these pseudogenization events took place recently in a common ancestor." |
10.1016/j.celrep.2014.12.008 |
| Phenotypic |
"Both CPA1 and CPA2 are expressed mainly in pancreas and play an important role in protein digestion and absorption18. Therefore, the loss of CPA2 is likely to be related to the specialized diet of cetaceans." |
10.1016/j.celrep.2014.12.008 |