Ψ CPA3 - Balaena mysticetus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_RZD9M5 | Balaena mysticetus | LOF (frameshift, premature stop, ss) | Full | No | Genomic & Transcriptomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Several paralogues of carboxypeptidase A from the M14 family of metalloproteases have been pseudogenized in bowhead and minke whales. Thus, CPA2 and CPA3 show premature stop codons in bowhead whale (Supplemental Data File 1)." | 10.1016/j.celrep.2014.12.008 |
| Phenotypic | "The loss of CPA3 might be related to the same adaptive mechanism, since this enzyme is also found in pancreatic secretions. Interestingly, CPA3 has also been studied in connection to the modulation of innate immune response and blood pressure, which suggests that the loss of this protein might be involved in adaptation to the aquatic environment." | 10.1016/j.celrep.2014.12.008 |
Curator Observations
See supplementary material for details.