Ψ PRSS33 - Balaena mysticetus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_5ULHOR | Balaena mysticetus | LOF (frameshift, premature stop, ss) | Full | No | Genomic & Transcriptomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "The serine protease PRSS33 has been lost in cetaceans through two conserved premature stop codons (Supplemental Data File 1)." | 10.1016/j.celrep.2014.12.008 |
| Phenotypic | "Notably, all known losses of this macrophage-specific gene in mammals are independent. Chimpanzees lost PRSS33 through an Alu-mediated recombination mechanism12,13, whereas the orthologs in orangutans and rhesus monkeys show different premature stop codons14. Therefore, this protease has been independently lost in multiple mammals, including cetaceans, probably reflecting the need for quick evolution of the immune system in different circumstances." | 10.1016/j.celrep.2014.12.008 |
Curator Observations
See supplementary material for details.