Ψ MMP20 - Balaena mysticetus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_OTZUKH | Balaena mysticetus | LOF (frameshift, premature stop, ss) | Full | No | Genomic & Transcriptomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "We have found that the pseudogenization of bowhead whale MMP20 has followed a different path to that of minke whale (Supplemental Data File 1). Thus, unlike the minke whale ortholog, the predicted open reading frame of bowhead whale MMP20 contains no early stop codons. Instead, the initiation methionine has been mutated to an isoleucine, which is expected to hamper translation of an active protein. Even if a different methionine residue were used as initiator, the resulting protein would lose its signal peptide, which is necessary for its extracellular function." | 10.1016/j.celrep.2014.12.008 |
| Phenotypic | "Therefore, the loss of both KLK4 and MMP20 is likely to be related to the loss of teeth in the suborder Mysticeti." | 10.1016/j.celrep.2014.12.008 |
Curator Observations
See supplementary material for details.
Related Glosses
| GL_ID | Symbol | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|---|
| GL_ENZCWX | MMP20 | Balaena mysticetus | Artiodactyla | Other | Full | 10.1098/rspb.2010.1280 |