Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| KLK4 kallikrein related peptidase 4 | ARM1 , EMSP , PSTS , AI2A1 , EMSP1 , KLK-L1 , PRSS17 , kallikrein | Homo sapiens | 6 | protein-coding | GZMK , GZMA , CFD , AZU1 , GZMM , PRSS57 , CMA1 , GZMH , CTSG , GZMB , KLK3 , KLK2 , KLK1 , KLK6 , KLK15 , KLK13 , KLK14 , KLK11 , KLK8 , KLK7 , KLK5 , KLK9 , KLK10 , PRSS37 , PRSS58 , KLK12 | 603767 |
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]
GeneOntology
Gene Loss events - KLK4 (19 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_1XHPXZ | Balaenoptera edeni | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_23PIV1 | Neophocaena asiaeorientalis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_5MGNZQ | Eubalaena australis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_5W1BR0 | Kogia sima | Artiodactyla | Exon(s) deletion | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_7KURRW | Balaenoptera physalus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_AW0CQN | Balaenoptera borealis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_AXC4FX | Balaena mysticetus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_BVYI5Z | Eubalaena glacialis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_C2W1KV | Balaenoptera bonaerensis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Mysticeti | 10.1016/j.ympev.2022.107463 |
| GL_COFP6V | Phocoena phocoena | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |