Ψ KLK4 - Eubalaena australis

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_5MGNZQ Eubalaena australis LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Functional "Seven of these genes are enamel specific (ACP4, AMBN, AMELX, AMTN, ENAM, KLK4, MMP20) and two are related to dentin/tooth formation (...)." 10.1016/j.ympev.2022.107463
Mutation Description "Of the seven enamel genes, three (ACP4, KLK4, MMP20) were found to have inactivating mutations that are shared by all mysticetes. ACP4 has a 1-bp deletion in exon 4; KLK4 has a 1-bp deletion in exon 3; and MMP20 has a SINE insertion in exon 2." 10.1016/j.ympev.2022.107463
Timing of Loss "34,62 MYA" 10.1016/j.ympev.2022.107463

Curator Observations

See table 3 for details regarding mutations.