Ψ KLK4 - Balaena mysticetus

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_I0WN9Q Balaena mysticetus LOF (frameshift, premature stop, ss) Full No Genomic & Transcriptomic

Statements

Type Excerpt DOI
Functional "This protease is involved in dental enamel formation, and its pseudogenization in mammals, in concert with that of the metalloprotease MMP20, leads to amelogenesis imperfecta in mammals." 10.1016/j.celrep.2014.12.008
Mutation Description "KLK4 was pseudogenized through a frameshift mutation in a common ancestor to both whales, but not in dolphins (Supplemental Data File 1)." 10.1016/j.celrep.2014.12.008
Phenotypic "Therefore, the loss of both KLK4 and MMP20 is likely to be related to the loss of teeth in the suborder Mysticeti." 10.1016/j.celrep.2014.12.008

Curator Observations

See supplementary material for details.

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_AXC4FX KLK4 Balaena mysticetus Artiodactyla LOF (frameshift, premature stop, ss) Full Mysticeti 10.1016/j.ympev.2022.107463