Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| TLR5 toll like receptor 5 | SLE1 , TIL3 , SLEB1 , MELIOS | Homo sapiens | 7 | protein-coding | TLR10 , TLR1 , TLR6 , TLR2 , TLR4 | 603031 |
Summary
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Knockout
https://www.jax.org/strain/008377
IMSR_JAX:008377
GeneOntology
Gene Loss events - TLR5 (14 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_2M64GS | Neomonachus schauinslandi | Carnivora | LOF (frameshift, premature stop, ss) | Full | Phocidae | 10.1093/molbev/msaa058 |
| GL_3O1UZW | Cavia porcellus | Rodentia | LOF (frameshift, premature stop, ss) | Full | Cavia | 10.1093/molbev/msaa058 |
| GL_6E6IYX | Arctocephalus gazella | Carnivora | LOF (frameshift, premature stop, ss) | Full | Otariidae | 10.1093/molbev/msaa058 |
| GL_9XZNMS | Leptonychotes weddellii | Carnivora | LOF (frameshift, premature stop, ss) | Full | Phocidae | 10.1093/molbev/msaa058 |
| GL_CER3KH | Phataginus tricuspis | Pholidota | Gene deletion | Full | Pholidota | 10.1093/molbev/msaa058 |
| GL_H3T9RU | Inia geoffrensis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Iniidae | 10.1093/molbev/msaa058 |
| GL_ILUI34 | Manis pentadactyla | Pholidota | Gene deletion | Full | Pholidota | 10.1093/molbev/msaa058 |
| GL_JXJRR0 | Lipotes vexillifer | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Lipotidae | 10.1093/molbev/msaa058 |
| GL_LMN9TY | Manis javanica | Pholidota | Gene deletion | Full | Pholidota | 10.1093/molbev/msaa058 |
| GL_LSDI8N | Cavia aperea | Rodentia | LOF (frameshift, premature stop, ss) | Full | Cavia | 10.1093/molbev/msaa058 |