Ψ TLR5 - Neomonachus schauinslandi
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_2M64GS | Neomonachus schauinslandi | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | 110571356 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Similarly, while no sequencing reads are available to confirm mutations in the Hawaiian monk seal assembly, we found that six of seven observed mutations are shared with the Weddell seal (fig. 1A), providing strong support that TLR5 is lost in the Hawaiian monk seal." | 10.1093/molbev/msaa058 |
| Timing of Loss | "Together, the presence of inactivating mutations shared between Otariidae, Phocidae, and Odobenidae suggests that TLR5 loss already occurred in the pinniped stem lineage at least aprox.26Ma (the estimated split of pinnipeds according to TimeTree." | 10.1093/molbev/msaa058 |