Ψ TLR5 - Leptonychotes weddellii
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_9XZNMS | Leptonychotes weddellii | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic & Transcriptomic | 102729859 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "In contrast to these nine species, all frameshifts and stop codon mutations present in the domestic guinea pig, Weddell seal, and Pacific walrus were confirmed by several sequencing reads and we found no support for the ancestral, noninactivating allele (fig. 1A, supplementary table 2, Supplementary Material online)." | 10.1093/molbev/msaa058 |
| Timing of Loss | "Together, the presence of inactivating mutations shared between Otariidae, Phocidae, and Odobenidae suggests that TLR5 loss already occurred in the pinniped stem lineage at least aprox.26Ma (the estimated split of pinnipeds according to TimeTree." | 10.1093/molbev/msaa058 |