| Mutation Description |
"To investigate whether TLR5 loss is specific to the domestic guinea pig or whether this gene is also lost in wild guinea pig species, we analyzed the TLR5 locus in the genomes of two additional guinea pigs which are not a part of our genome alignment—Brazilian and Montane guinea pigs. As shown in figure 1A, both stop codons and the 2 bp deletion are shared between all three guinea pig species. Additionally, the large deletion that removes most of the TLR5 coding exon has the same breakpoints in all three guinea pig species (fig. 1B), which makes an assembly error highly unlikely and suggests that this deletion already occurred in their common ancestor." |
10.1093/molbev/msaa058 |