Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
AWAT1 acyl-CoA wax alcohol acyltransferase 1 DGA2 , DGAT2L3 Homo sapiens 7 DGAT2L6, AWAT2, DGAT2, MOGAT3, MOGAT2, MOGAT1 2.3.1.75 300924

Summary

The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]

GeneOntology

Gene Loss events - AWAT1 (23 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_0D0OES Balaenoptera musculus Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1093/molbev/msz068
GL_0YLKKQ Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1016/j.cub.2021.02.057
GL_10QJU4 Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full Pholidota 10.1007/s00239-023-10118-z
GL_2MFD5D Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1093/molbev/msz068
GL_4M0ONI Hexaprotodon liberiensis Artiodactyla LOF (frameshift, premature stop, ss) Full Hippopotamidae 10.1016/j.cub.2021.02.057
GL_73WR4W Manis javanica Pholidota LOF (frameshift, premature stop, ss) Full Pholidota 10.1007/s00239-023-10118-z
GL_9IB1LO Balaena mysticetus Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1093/molbev/msz068
GL_AH71VN Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1093/molbev/msz068
GL_BMJDCK Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1093/molbev/msz068
GL_CZ9QH1 Sus scrofa Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1093/molbev/msz068