Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| AWAT1 acyl-CoA wax alcohol acyltransferase 1 | DGA2 , DGAT2L3 | Homo sapiens | 7 | DGAT2L6, AWAT2, DGAT2, MOGAT3, MOGAT2, MOGAT1 | 2.3.1.75 | 300924 |
Summary
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
GeneOntology
Gene Loss events - AWAT1 (23 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_RUUOWW | Tursiops truncatus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1093/molbev/msz068 |
| GL_UTX7B7 | Hippopotamus amphibius | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Hippopotamidae | 10.1016/j.cub.2021.02.057 |
| GL_YGOIBS | Phataginus tricuspis | Pholidota | LOF (frameshift, premature stop, ss) | Full | Pholidota | 10.1007/s00239-023-10118-z |