Ψ AWAT1 - Hexaprotodon liberiensis

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_4M0ONI Hexaprotodon liberiensis LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Functional "Produces wax esters in sebaceous glands." 10.1016/j.cub.2021.02.057
Mutation Description "I - Insertion; D - Deletion "100-103I (exon 2) 309D (exon 4) 378-381D (exon 4) 630I (exon 5) 792-802D (exon 6) 931-934D (exon 7)"" 10.1016/j.cub.2021.02.057
Timing of Loss ""Our results confirm the independent inactivation of AWAT1 and further suggest that AWAT1 was inactivated in the common ancestor of H. amphibius and Choeropsis liberiensis."; 53.92 MA" 10.1016/j.cub.2021.02.057
Phenotypic ""cetaceans have inactivating mutations in genes (AWAT1, DGAT2L6, FABP9, ELOVL3, MOGAT3, and MC5R) associated with sebaceous gland function."" 10.1016/j.cub.2021.02.057
Other "Eight of nine genes (ALOX15, AWAT1, KPRP, KRT2, KRT26, KRT77, KRTAP7-1, and TCHHL1) exhibit shared inactivating mutations in both hippopotamid species" 10.1016/j.cub.2021.02.057

Curator Observations

See Table 2 for details regarding timing of loss. See Supplementary Table 2 for details regarding inactivating mutations