Ψ AWAT1 - Balaena mysticetus

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_9IB1LO Balaena mysticetus LOF (frameshift, premature stop, ss) Full Yes Single individual SRA

Statements

Type Excerpt DOI
Mutation Description "In the case of Awat1, exons 4–7 were not found in all investigated species, possibly due to poor genome coverage or complete exon deletion." 10.1093/molbev/msz068
Mutation Description "In addition to the potential exon loss in Awat1, a conserved stop codon was identified in exon 2 in all analyzed Cetacea species." 10.1093/molbev/msz068
Timing of Loss "Interestingly, the mutational pattern deduced in Dgat2l6, Mogat3, Awat1, Elovl3, and Fabp9 allowed the identification of conserved founding mutations common to all analyzed Cetacea (fig. 4). The sharing of mutations constitutes a strong indication of common pseudogenization events prior to the diversification of modern Cetacea lineages." 10.1093/molbev/msz068
Phenotypic "In conclusion, our study supports convergent gene loss events in key molecular components responsible for skin sebum production in lineages reported to lack functioning SGs (Sebaceous Glands)." 10.1093/molbev/msz068