Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
MTNR1B melatonin receptor 1B MT2 , FGQTL2 , MEL-1B-R Homo sapiens 4 MNTR1A 600804

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

Gene Loss events - MTNR1B (13 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_12VABL Eschrichtius robustus Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_2GEKKB Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_7QIBOC Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_A8IVPZ Balaenoptera bonaerensis Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_DH9TMC Balaena mysticetus Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_DQYBFD Trichechus manatus Sirenia LOF (frameshift, premature stop, ss) Full 10.3390/genes10020121
GL_FB7GDM Sousa chinensis Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_HH8TEJ Lagenorhynchus obliquidens Artiodactyla Exon(s) deletion Full Cetacea 10.3390/genes10020121
GL_HMH397 Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_JMMCA1 Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121