Ψ MTNR1B - Manis pentadactyla

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_2IVENS Manis pentadactyla LOF (frameshift, premature stop, ss) Full Yes Multiple individual SRA XM_057508188.1 

Statements

Type Excerpt DOI
Functional "In mammals, Mtnr1a and Mtnr1b receptors are involved in the response of the clock machinery to melatonin stimulation (Reppart et al. 1996)." 10.1007/s00239-021-10025-1
Mutation Description "Examples of conserved inactivating mutations were found in bears (Ursus sp.) with an in-frame premature stop codon in exon 1, weasels (Mustela sp.) sharing several indels in exon 2 and pangolins with a single nucleotide deletion and an in frame premature stop codon in exon 1 (Online Resources 4 and 13)." 10.1007/s00239-021-10025-1
Methodology & Validation "Mutational validation was performed through retrieval of raw sequencing reads in (at least) two independent Sequence Read Archive (SRA) projects (when available)." 10.1007/s00239-021-10025-1

Curator Observations

Consult Supplementary Data 4 and 13.