Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
MTNR1B melatonin receptor 1B MT2 , FGQTL2 , MEL-1B-R Homo sapiens 4 MNTR1A 600804

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

Gene Loss events - MTNR1B (62 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_6AF5T8 Globicephala melas Artiodactyla Exon(s) deletion Full No 10.1007/s00239-021-10025-1
GL_7PUPJH Nannospalax galili Rodentia LOF (frameshift, premature stop, ss) Full No 10.1007/s00239-021-10025-1
GL_7QIBOC Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_7YDVUB Rhinolophus ferrumequinum Chiroptera LOF (frameshift, premature stop, ss) Polymorphic No 10.1007/s00239-021-10025-1
GL_A68VIY Mustela putorius furo Carnivora LOF (frameshift, premature stop, ss) Full Mustela 10.1007/s00239-021-10025-1
GL_A8IVPZ Balaenoptera bonaerensis Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.3390/genes10020121
GL_AOCQMX Sorex araneus Eulipotyphla Exon(s) deletion Full No 10.1007/s00239-021-10025-1
GL_BE2K47 Neomonachus schauinslandi Carnivora LOF (frameshift, premature stop, ss) Full No 10.1007/s00239-021-10025-1
GL_BKFL1I Dugong dugon Sirenia LOF (frameshift, premature stop, ss) Full No 10.1007/s00239-021-10025-1
GL_CVJQBJ Phoca vitulina Carnivora LOF (frameshift, premature stop, ss) Full No 10.1007/s00239-021-10025-1