Gene Loss

Publication Details

Identifier: JB_UNTSYT

Curator: Gonçalo Themudo

DOI: 10.1038/s41467-018-03667-1

PMID: 29572503

Title:

A genomics approach reveals insights into the importance of gene losses for mammalian adaptations.

Abstract:

Identifying the genomic changes that underlie phenotypic adaptations is a key challenge in evolutionary biology and genomics. Loss of protein-coding genes is one type of genomic change with the potential to affect phenotypic evolution. Here, we develop a genomics approach to accurately detect gene losses and investigate their importance for adaptive evolution in mammals. We discover a number of gene losses that likely contributed to morphological, physiological, and metabolic adaptations in aquatic and flying mammals. These gene losses shed light on possible molecular and cellular mechanisms that underlie these adaptive phenotypes. In addition, we show that gene loss events that occur as a consequence of relaxed selection following adaptation provide novel insights into species' biology. Our results suggest that gene loss is an evolutionary mechanism for adaptation that may be more widespread than previously anticipated. Hence, investigating gene losses has great potential to reveal the genomic basis underlying macroevolutionary changes.

Last update:

13-01-2025

Associated Glosses (111 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_WME7BH	Cavia porcellus	MLN	Other	Full	No	10.1038/s41467-018-03667-1
GL_XYNFGC	Trichechus manatus	KRT82	Other	Full	No	10.1038/s41467-018-03667-1
GL_Y7KJSS	Pteropus vampyrus	AQP6	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41467-018-03667-1
GL_YGAIR6	Physeter catodon	DSG4	Exon(s) deletion	Full	Cetacea	10.1038/s41467-018-03667-1
GL_YPRQRT	Balaenoptera acutorostrata	TGM5	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1038/s41467-018-03667-1
GL_YROE1P	Nannospalax galili	GUCY2F	Other	Full	No	10.1038/s41467-018-03667-1
GL_YYMOP2	Physeter catodon	KLK8	Other	Full	No	10.1038/s41467-018-03667-1
GL_ZJA5SJ	Physeter catodon	ALOXE3	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41467-018-03667-1
GL_ZNR2E4	Cavia porcellus	ABCB4	Other	Full	No	10.1038/s41467-018-03667-1
GL_ZSX2KT	Physeter catodon	MX1	Other	Full	No	10.1038/s41467-018-03667-1