Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| GUCY2F guanylate cyclase 2F, retinal | CYGF , GC-F , GUC2F , GUC2DL , RETGC-2 , ROS-GC2 | Homo sapiens | 20 | protein-coding | NPR1 , NPR2 , GUCY2D , GUCY2C | 4.6.1.2 | 300041 |
Summary
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]
GeneOntology
Gene Loss events - GUCY2F (17 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_3DPZ1D | Chrysochloris asiatica | Afrosoricida | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_4EDDQQ | Nannospalax galili | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_6HZIZS | Sorex araneus | Eulipotyphla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_CBRLYQ | Heterocephalus glaber | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_CQ8I6V | Echinops telfairi | Gene deletion | Full | No | 10.1093/icb/icy004 | |
| GL_ESYBKS | Mesoplodon perrini | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/molbev/msaa070 |
| GL_FQM84K | Manis javanica | Pholidota | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_GU4SPV | Tupaia chinensis | Scandentia | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_HWFJUI | Fukomys damarensis | Rodentia | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_LQQYNO | Hipposideros armiger | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |