Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| MX1 MX dynamin like GTPase 1 | MX , MxA , IFI78 , IFI-78K , lncMX1-215 | Homo sapiens | 20 | protein-coding | OPA1 , DNM1L , MX2 , DNM2 , DNM3 , DNM1 | 147150 |
Summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Loss events - MX1 (3 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_CEUYBX | Orcinus orca | Artiodactyla | Other | Full | No | 10.1038/s41467-018-03667-1 |
| GL_NNSUXK | Tursiops truncatus | Artiodactyla | Other | Full | No | 10.1038/s41467-018-03667-1 |
| GL_ZSX2KT | Physeter catodon | Artiodactyla | Other | Full | No | 10.1038/s41467-018-03667-1 |