Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
ALOXE3 arachidonate epidermal lipoxygenase 3 LI5 , ARCI3 , E-LOX , eLOX3 , eLOX-3 Homo sapiens 19 protein-coding ALOX12B , ALOX15B , ALOX5 , ALOX15 , ALOX12 4.2.1.152 , 5.4.4.7 607206

Summary

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Loss events - ALOXE3 (4 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_74A8CT Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1
GL_9ZZXTA Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1
GL_HDV9ZD Balaenoptera acutorostrata Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1
GL_ZJA5SJ Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41467-018-03667-1