Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CORT cortistatin	SST2 , CST-14 , CST-17 , CST-29	Homo sapiens	2	protein-coding			602784

Summary

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0001664	enables G protein-coupled receptor binding	IBA

Component (4)

Go ID	Value	Evidence
0005576	located_in extracellular region	TAS
0005615	is_active_in extracellular space	IBA
0005615	located_in extracellular space	NAS
0045202	located_in synapse	IEA

Process (4)

Go ID	Value	Evidence
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
0007268	involved_in chemical synaptic transmission	NAS
0030334	involved_in regulation of cell migration	IBA

Gene Loss events - CORT (63 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_D0I8QT	Manis javanica	Pholidota	LOF (frameshift, premature stop, ss)	Full	Pholidota	10.1016/j.ygeno.2020.11.002
GL_D0UNTP	Heterohyrax brucei	Hyracoidea	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_D5EANL	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.ygeno.2020.11.002
GL_D95CWE	Canis lupus familiaris	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_DWWIXF	Paradoxurus hermaphroditus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_DWZVOD	Choloepus hoffmanni	Pilosa	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_E8CJY9	Tapirus indicus	Perissodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_EAUFKA	Myrmecophaga tridactyla	Pilosa	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_F6BTFZ	Phocoena phocoena	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Phocoenidae	10.1016/j.ygeno.2020.11.002
GL_FN3UGO	Platanista gangetica	Artiodactyla	LOF (frameshift, premature stop, ss)	Undetermined	No	10.1016/j.ygeno.2020.11.002