Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CORT cortistatin	SST2 , CST-14 , CST-17 , CST-29	Homo sapiens	2	protein-coding			602784

Summary

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0001664	enables G protein-coupled receptor binding	IBA

Component (4)

Go ID	Value	Evidence
0005576	located_in extracellular region	TAS
0005615	is_active_in extracellular space	IBA
0005615	located_in extracellular space	NAS
0045202	located_in synapse	IEA

Process (4)

Go ID	Value	Evidence
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
0007268	involved_in chemical synaptic transmission	NAS
0030334	involved_in regulation of cell migration	IBA

Gene Loss events - CORT (63 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_GQSIY9	Neophocaena asiaeorientalis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full		10.1016/j.ygeno.2020.11.002
GL_GUUD1S	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_HCUPFP	Lynx pardinus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_HHDJKR	Puma concolor	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_HTJBYM	Suricata suricatta	Carnivora	LOF (frameshift, premature stop, ss)	Undetermined	No	10.1016/j.ygeno.2020.11.002
GL_IUY67P	Vulpes lagopus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_JJRGZX	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Undetermined	No	10.1016/j.ygeno.2020.11.002
GL_KMLI8B	Ursus thibetanus thibetanus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_KZZFLG	Inia geoffrensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Undetermined	No	10.1016/j.ygeno.2020.11.002
GL_LG8MF3	Hyaena hyaena	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002