Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CORT cortistatin	SST2 , CST-14 , CST-17 , CST-29	Homo sapiens	2	protein-coding			602784

Summary

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0001664	enables G protein-coupled receptor binding	IBA

Component (4)

Go ID	Value	Evidence
0005576	located_in extracellular region	TAS
0005615	is_active_in extracellular space	IBA
0005615	located_in extracellular space	NAS
0045202	located_in synapse	IEA

Process (4)

Go ID	Value	Evidence
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
0007268	involved_in chemical synaptic transmission	NAS
0030334	involved_in regulation of cell migration	IBA

Gene Loss events - CORT (63 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_7UBIN7	Ursus maritimus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_8YZGK0	Crocuta crocuta	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_9XF3FB	Lynx canadensis	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_ARX9XL	Helogale parvula	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_AVMCHP	Lagenorhynchus obliquidens	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.ygeno.2020.11.002
GL_AXZI0G	Condylura cristata	Eulipotyphla	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_BFJER9	Megaderma lyra	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_BSKFKD	Acinonyx jubatus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002
GL_CHBICG	Delphinapterus leucas	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Monodontidae	10.1016/j.ygeno.2020.11.002
GL_CLJCWU	Panthera onca	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ygeno.2020.11.002