Ψ CORT - Lagenorhynchus obliquidens

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_AVMCHP Lagenorhynchus obliquidens LOF (frameshift, premature stop, ss) Full Yes Multiple individual SRA

Statements

Type Excerpt DOI
Mutation Description "Further mutational evidence revealed that in Odontoceti (toothed whales and dolphins), all Delphinoidea, including Delphinidae (dolphins, e.g. Tursiops truncatus, Orcinus orca), Phocoenidae (porpoises, e.g. Phocoena phocoena), and Monodontidae (narwhal, Monodon monoceros, and beluga whale, Delphinapterus leucas), exhibited a conserved stop codon mutation in exon 1 (Fig. 1), with the exception of O. orca, which displays an arginine codon in the same position (CGA)." 10.1016/j.ygeno.2020.11.002
Phenotypic "Both hyperglycaemia and insulin resistance were also reported in dolphins, in addition to reduced carbohydrate intake [45]; thus, besides modulating sleep, CORT loss could also be correlated with diet and energy balance within this group." 10.1016/j.ygeno.2020.11.002
Phenotypic "Thus, it is plausible to hypothesize that, in these species, CORT inactivation is related with changes in circadian rhythmicity, affecting sleep/vigilance behaviours, body temperature maintenance and/or activity patterns." 10.1016/j.ygeno.2020.11.002

Curator Observations

Authores manually annotated this gene.