| Mutation Description |
"Further mutational evidence revealed that in Odontoceti (toothed whales and dolphins), all Delphinoidea, including Delphinidae (dolphins, e.g. Tursiops truncatus, Orcinus orca), Phocoenidae (porpoises, e.g. Phocoena phocoena), and Monodontidae (narwhal, Monodon monoceros, and
beluga whale, Delphinapterus leucas), exhibited a conserved stop codon mutation in exon 1 (Fig. 1), with the exception of O. orca, which displays an arginine codon in the same position (CGA)." |
10.1016/j.ygeno.2020.11.002 |
| Mutation Description |
"In O. orca, Tursiops, and S. chinensis, exon 2 also presented a frameshift mutation (1-nucleotide deletion), a pattern not consistent with the species branching tree topology [31] (Fig. 1)." |
10.1016/j.ygeno.2020.11.002 |
| Mutation Description |
"Yet, given the striking conservation of the premature stop codon across the analysed Delphinoidea and the single nucleotide difference between both codons, the Orca exception likely represents a case of mutational reversion (Stop>Arg, TGA > CGA) [30]. Nonetheless, in addition to the premature
stop codon, other mutations were identified, confirming the erosion of CORT in O. orca, such as frameshifts in exon 1 (a 31-nucleotide deletion and a 2-nucleotide insertion), conserved in all Delphinidae (Fig. 1)." |
10.1016/j.ygeno.2020.11.002 |
| Phenotypic |
"Both hyperglycaemia and insulin resistance were also reported in dolphins, in addition to reduced
carbohydrate intake [45]; thus, besides modulating sleep, CORT loss could also be correlated with diet and energy balance within this group." |
10.1016/j.ygeno.2020.11.002 |
| Phenotypic |
"Thus, it is plausible to hypothesize that, in these species, CORT inactivation is related with changes in circadian rhythmicity, affecting sleep/vigilance behaviours, body temperature maintenance and/or activity patterns." |
10.1016/j.ygeno.2020.11.002 |