Ψ CORT - Phocoena phocoena

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_F6BTFZ Phocoena phocoena LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Mutation Description "Further mutational evidence revealed that in Odontoceti (toothed whales and dolphins), all Delphinoidea, including Delphinidae (dolphins, e.g. Tursiops truncatus, Orcinus orca), Phocoenidae (porpoises, e.g. Phocoena phocoena), and Monodontidae (narwhal, Monodon monoceros, and beluga whale, Delphinapterus leucas), exhibited a conserved stop codon mutation in exon 1 (Fig. 1), with the exception of O. orca, which displays an arginine codon in the same position (CGA)." 10.1016/j.ygeno.2020.11.002
Mutation Description "Additionally, deleterious mutations were also found across all members of Phocoenidae and Monodontidae (Fig. 1)." 10.1016/j.ygeno.2020.11.002
Phenotypic "Both hyperglycaemia and insulin resistance were also reported in dolphins, in addition to reduced carbohydrate intake [45]; thus, besides modulating sleep, CORT loss could also be correlated with diet and energy balance within this group." 10.1016/j.ygeno.2020.11.002
Phenotypic "Thus, it is plausible to hypothesize that, in these species, CORT inactivation is related with changes in circadian rhythmicity, affecting sleep/vigilance behaviours, body temperature maintenance and/or activity patterns." 10.1016/j.ygeno.2020.11.002

Curator Observations

Authors manually annotated this gene.