Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| FGF22 fibroblast growth factor 22 | Homo sapiens | 3 | protein-coding | FGF8 , FGF18 , FGF17 , FGF7 , FGF10 , FGF3 , FGF12 , FGF11 , FGF13 , FGF14 , FGF9 , FGF21 , FGF19 , FGF23 , FGF6 , FGF4 , FGF5 , FGF16 , FGF20 , FGF2 , FGF1 | 605831 |
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Loss events - FGF22 (9 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_BFAHF4 | Balaena mysticetus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_ND0VW1 | Orcinus orca | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_O0RVTU | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_OZKWYM | Loxodonta africana | Proboscidea | Exon(s) deletion | Full | No | 10.1038/srep40233 |
| GL_PZB0AJ | Tursiops truncatus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_STGBER | Balaenoptera physalus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_U5NY8V | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_U9JRFI | Neophocaena phocaenoides | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |
| GL_UNQBRO | Lipotes vexillifer | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/srep40233 |