| Functional |
"FGF22 is preferentially expressed in the inner root sheath of the hair follicle40, but its role in hair development or maintenance is not yet clearly understood41" |
10.1038/srep40233 |
| Mutation Description |
"Unlike FGF3, independent nonsense or frameshift mutations that destroyed the highly conserved FGF domain were found in FGF22, a gene related with hair follicles, from all cetaceans examined." |
10.1038/srep40233 |
| Timing of Loss |
"FGF22 was pseudogenized after the divergence of the toothed and baleen whales (Fig. 1 and Supplementary Figs S3 and S4)." |
10.1038/srep40233 |
| Phenotypic |
"The parallel loss of FGF22 in cetaceans and African elephant indicates the importance of FGF22 in the maintenance or control of the density of hair in mammals." |
10.1038/srep40233 |
| Other |
"The independent, damaging mutations in baleen and toothed whales suggest that FGF22 was no longer necessary when the common ancestor of the cetaceans lost its body hair" |
10.1038/srep40233 |