| Functional |
"Interestingly, we also found damaging mutations in African elephant, an animal with very sparse hair (Fig. 1). The African elephant has lost most of its body hair in response to the high demand for efficient heat transfer because it has the largest body volume to surface area ratio among terrestrial mammals and lives in hot environments." |
10.1038/srep40233 |
| Mutation Description |
"Interestingly, we also noticed a loss of FGF22 in African elephant as judged by a complete loss of exon 1 and one nucleotide insertion in exon 2 (Fig. 1 and Supplementary Figs S3 and S4)." |
10.1038/srep40233 |
| Timing of Loss |
"FGF22 was pseudogenized after the divergence of the toothed and baleen whales (Fig. 1 and Supplementary Figs S3 and S4)." |
10.1038/srep40233 |
| Phenotypic |
"The parallel loss of FGF22 in cetaceans and African elephant indicates the importance of FGF22 in the maintenance or control of the density of hair in mammals." |
10.1038/srep40233 |