Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GSDMA gasdermin A	GSDM , FKSG9 , GSDM1	Homo sapiens	14		GSDMD GSDMC GSDMB PJVK		611218

Summary

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Involved in apoptotic process. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005546	enables phosphatidylinositol-4,5-bisphosphate binding	IBA

Component (4)

Go ID	Value	Evidence
0005829	located_in cytosol	IEA
0016020	is_active_in membrane	IDA
0048471	located_in perinuclear region of cytoplasm	IDA
0005886	located_in plasma membrane	IEA

Process (5)

Go ID	Value	Evidence
0042742	involved_in defense response to bacterium	IBA
0042742	involved_in defense response to bacterium	IDA
0070269	involved_in pyroptosis	IBA
0070269	involved_in pyroptosis	IDA
0055085	involved_in transmembrane transport	IEA

Gene Loss events - GSDMA (3 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_NBWWKO	Manis pentadactyla	Pholidota	Exon(s) deletion	Full	Manis	10.1007/s00239-023-10118-z
GL_Q32ZSQ	Manis javanica	Pholidota	Exon(s) deletion	Full	Manis	10.1007/s00239-023-10118-z
GL_WYE0DR	Manis crassicaudata	Pholidota	Exon(s) deletion	Full	Manis	10.1007/s00239-023-10118-z