Ψ GSDMA - Balaenoptera acutorostrata
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_5W933N | Balaenoptera acutorostrata | LOF (frameshift, premature stop, ss) | Full | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "The genome sequences (…) were investigated for the presence and sequence integrity of genes related to pyroptosis and IL-1 signaling. Comparative genomics showed conservation of GSDMD and inactivation of the GSDMA, GSDMB, GSDMC and GSDME genes in cetaceans (Fig. 2F; Suppl. Fig. S8; Suppl. Table S2)» (Lachner et al., 2017, p. 3)." | 10.1038/s41598-017-17782-4 |
| Phenotypic | "Despite efficient suppression of GSDMA expression (Suppl. Fig. S9A–C), keratinocytes cornified and formed an orthokeratotic (nuclei-free) stratum corneum (Suppl. Fig. S9D,E), suggesting that gasdermin A is not required for terminal differentiation-associated death of human keratinocytes." | 10.1038/s41598-017-17782-4 |
Curator Observations
Figure 2 and Supplementary Table 2.
Related Glosses
| GL_ID | Symbol | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|---|
| GL_0MLL6N | GSDMA | Balaenoptera acutorostrata | Artiodactyla | Exon(s) deletion | Full | Cetacea | 10.1038/s41467-018-03667-1 |