Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TAS1R1 taste 1 receptor member 1	TR1 , T1R1 , GM148 , GPR70	Homo sapiens	7	protein-coding	GPRC6A , TAS1R2 , TAS1R3 , CASR		606225

Summary

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (3)

Go ID	Value	Evidence
0016020	located_in membrane	IC
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	TAS

Process (4)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IEA
0050912	involved_in detection of chemical stimulus involved in sensory perception of taste	IEA
0050917	involved_in sensory perception of umami taste	IBA
0050917	involved_in sensory perception of umami taste	IDA

Gene Loss events - TAS1R1 (19 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_NS38RZ	Kogia sima	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_NVYXIP	Ailuropoda melanoleuca	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00114-012-0939-8
GL_RLTQ47	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_U8CHMS	Otaria byronia	Carnivora	LOF (frameshift, premature stop, ss)	Full	Otariidae	10.1007/s00114-012-0939-8
GL_UZLRF1	Tursiops truncatus	Artiodactyla	Other	Full	No	10.1038/s41467-018-03667-1
GL_V1TW1L	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_WAXIQA	Zalophus californianus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_Y4DTNF	Balaenoptera omurai	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_Z6LPE1	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s40851-014-0002-z