Gene Loss

Publication Details

Identifier: JB_RXKDGW

Curator: Gonçalo Themudo

Title:

Comparative genomics provides insights into the aquatic adaptations of mammals.

Abstract:

The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, we reconstructed the marine mammal phylogeny and population histories and identified numerous idiosyncratic and convergent genomic variations that possibly contributed to the transition from land to water in marine mammal lineages. Genes associated with the formation of blubber (NFIA), vascular development (SEMA3E), and heat production by brown adipose tissue (UCP1) had unique changes that may contribute to marine mammal thermoregulation. We also observed many lineage-specific changes in the marine mammals, including genes associated with deep diving and navigation. Our study advances understanding of the timing, pattern, and molecular changes associated with the evolution of mammalian lineages adapting to aquatic life.

Last update:

10-01-2025

Associated Glosses (25 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0UETKS	Balaenoptera acutorostrata	UCP1	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.2106080118
GL_4YL4DQ	Kogia breviceps	UCP1	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.2106080118
GL_5RZLLU	Pseudorca crassidens	UCP1	Gene deletion	Full	No	10.1073/pnas.2106080118
GL_8AHK60	Balaenoptera brydei	UCP1	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.2106080118
GL_8JGVE0	Phocoena phocoena	UCP1	Gene deletion	Full	No	10.1073/pnas.2106080118
GL_BJAESG	Balaena mysticetus	UCP1	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.2106080118
GL_BZIDO4	Physeter catodon	UCP1	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.2106080118
GL_CXWL99	Lagenorhynchus australis	UCP1	Gene deletion	Full	No	10.1073/pnas.2106080118
GL_FFY4MO	Neophocaena asiaeorientalis	UCP1	Gene deletion	Full	No	10.1073/pnas.2106080118
GL_H04KVN	Eschrichtius robustus	UCP1	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.2106080118