Ψ TMPRSS11B - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_276009 | Physeter catodon | LOF (frameshift, premature stop, ss) | Full | No | Multiple individual SRA | XM_055086329.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | " In our data set, F7 appears to be a functional gene in sperm whales, whereas both TMPRSS11F and TMPRSS11B have been lost through premature stop codons." | 10.1093/gbe/evx187 |
| Methodology & Validation | "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." | 10.1093/gbe/evx187 |
| Phenotypic | "A loss of several proteases in cetaceans suggests a trend towards a milder inflammatory response relevant to Peto’s paradox: A theory postulated to explain the lower relative incidence of cancer in large mammals (CaulinandMaley2011)." | 10.1093/gbe/evx187 |
Curator Observations
See supplementary material for more details. Authors indicate this gene is also lost in mysticetes, but do not provide further details.