Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
PGLYRP3 peptidoglycan recognition protein 3	PGRPIA , PGRP-Ialpha , PGLYRPIalpha	Homo sapiens	11	protein-coding	PGLYRP2 , PGLYRP4 , PGLYRP1		608197

Summary

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

GeneOntology

Function (1)

Go ID	Value	Evidence
0008745	enables N-acetylmuramoyl-L-alanine amidase activity	IEA

Component (3)

Go ID	Value	Evidence
0005576	located_in extracellular region	TAS
0016020	located_in membrane	NAS
0032991	part_of protein-containing complex	IDA

Process (9)

Go ID	Value	Evidence
0061844	involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA
0051701	involved_in biological process involved in interaction with host	IEA
0050830	involved_in defense response to Gram-positive bacterium	IDA
0016045	involved_in detection of bacterium	IDA
0045087	involved_in innate immune response	NAS
0031640	involved_in killing of cells of another organism	IDA
0032827	involved_in negative regulation of natural killer cell differentiation involved in immune response	IEA
0032689	involved_in negative regulation of type II interferon production	IEA
0009253	involved_in peptidoglycan catabolic process	IEA

Gene Loss events - PGLYRP3 (7 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0OWOEP	Balaenoptera musculus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41598-021-91863-3
GL_B2MTHV	Tursiops truncatus	Artiodactyla	Exon(s) deletion	Full	Cetacea	10.1126/sciadv.aaw6671
GL_CIRO8L	Physeter catodon	Artiodactyla	Exon(s) deletion	Full	Cetacea	10.1126/sciadv.aaw6671
GL_ESHDEE	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41598-021-91863-3
GL_FNHQC1	Balaenoptera acutorostrata	Artiodactyla	Exon(s) deletion	Full	Cetacea	10.1126/sciadv.aaw6671
GL_V7RYGK	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41598-021-91863-3
GL_ZWCZS7	Orcinus orca	Artiodactyla	Exon(s) deletion	Full	Cetacea	10.1126/sciadv.aaw6671