Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
GSDMC gasdermin C MLZE Homo sapiens 21 N/a 608384

Summary

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within intestinal epithelial cell development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Gene Loss events - GSDMC (9 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_0SYFUX Phataginus tricuspis Pholidota Other Undetermined No 10.1007/s00239-023-10118-z
GL_2BWSUA Manis crassicaudata Pholidota Other Undetermined No 10.1007/s00239-023-10118-z
GL_E8A4NQ Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_GQEI4E Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_N21JXJ Manis javanica Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_NI0DMS Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4
GL_WC2VGR Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full Manis 10.1007/s00239-023-10118-z
GL_WNIM1U Balaenoptera acutorostrata Artiodactyla Gene deletion Full No 10.1038/s41598-017-17782-4
GL_XJ4YGU Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1038/s41598-017-17782-4