Ψ GSDMC - Manis javanica
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_N21JXJ | Manis javanica | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Timing of Loss | "Numerous inactivating mutations were also retrieved, including mutations conserved between the novel genome assemblies of M. javanica and M. pentadactyla, such as a two-nucleotide deletion in exon 3, as well as two losses of splicing sites in exons 3 and 4" | 10.1007/s00239-023-10118-z |
| Phenotypic | "Gsdmb and Gsdmc, expressed in human keratinocytes, were also suggested to contribute to keratinocyte differentiation and cornification (Lachner et al.2017)." | 10.1007/s00239-023-10118-z |