Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CETP cholesteryl ester transfer protein	BPIFF , HDLCQ10	Homo sapiens	17	protein-coding			118470

Summary

The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneOntology

Function (1)

Go ID	Value	Evidence
0015485	enables cholesterol binding	IBA

Component (6)

Go ID	Value	Evidence
0070062	located_in extracellular exosome	HDA
0005576	located_in extracellular region	TAS
0005615	located_in extracellular space	IDA
0034364	part_of high-density lipoprotein particle	IBA
0034364	part_of high-density lipoprotein particle	IDA
0031982	located_in vesicle	IDA

Process (31)

Go ID	Value	Evidence
0042632	involved_in cholesterol homeostasis	IBA
0042632	involved_in cholesterol homeostasis	IMP
0008203	involved_in cholesterol metabolic process	IBA
0008203	involved_in cholesterol metabolic process	IDA
0008203	involved_in cholesterol metabolic process	IMP
0030301	involved_in cholesterol transport	IDA
0034375	involved_in high-density lipoprotein particle remodeling	IBA
0034375	involved_in high-density lipoprotein particle remodeling	IDA
0034375	involved_in high-density lipoprotein particle remodeling	IMP
0055088	involved_in lipid homeostasis	IDA
0006869	involved_in lipid transport	IDA
0034374	involved_in low-density lipoprotein particle remodeling	IBA
0034374	involved_in low-density lipoprotein particle remodeling	IDA
0010745	involved_in negative regulation of macrophage derived foam cell differentiation	IC
0046470	involved_in phosphatidylcholine metabolic process	IBA
0046470	involved_in phosphatidylcholine metabolic process	IDA
0055091	involved_in phospholipid homeostasis	IBA
0055091	involved_in phospholipid homeostasis	IDA
0015914	involved_in phospholipid transport	IEA
0032376	involved_in positive regulation of cholesterol transport	IDA
2001140	involved_in positive regulation of phospholipid transport	IDA
0010874	involved_in regulation of cholesterol efflux	IMP
0043691	involved_in reverse cholesterol transport	IC
0070328	involved_in triglyceride homeostasis	IBA
0070328	involved_in triglyceride homeostasis	IDA
0006641	involved_in triglyceride metabolic process	IBA
0006641	involved_in triglyceride metabolic process	IDA
0034197	involved_in triglyceride transport	IBA
0034197	involved_in triglyceride transport	IDA
0034372	involved_in very-low-density lipoprotein particle remodeling	IBA
0034372	involved_in very-low-density lipoprotein particle remodeling	IDA

Gene Loss events - CETP (33 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_1GM33O	Myotis lucifugus	Chiroptera	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012
GL_508NW2	Otolemur garnettii	Primates	LOF (frameshift, premature stop, ss)	Full	No	10.1093/nargab/lqz012
GL_7APYQB	Tursiops truncatus	Artiodactyla	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012
GL_D6QGPJ	Rattus norvegicus	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1093/nargab/lqz012
GL_DMILRE	Mustela putorius furo	Carnivora	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012
GL_F55P9Y	Myotis davidii	Chiroptera	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012
GL_FS4GH6	Octodon degus	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1093/nargab/lqz012
GL_FYQZU1	Ceratotherium simum simum	Perissodactyla	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012
GL_IJPBKT	Capra hircus	Artiodactyla	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012
GL_JB8YPB	Pteropus alecto	Chiroptera	Exon(s) deletion	Full	Laurasiatheria	10.1093/nargab/lqz012