| Functional |
"CETP transfers cholesteryl ester from high-density lipoproteins (HDCs) to LDLs in exchange for triglycerides (105)." |
10.1093/nargab/lqz012 |
| Mutation Description |
"... CETP is lost in at least four independent lineages comprising a total of 33 mammals in our dataset
(Figure 2A; Supplementary Figures S8 and S9)." |
10.1093/nargab/lqz012 |
| Timing of Loss |
"The deletion of exons 14 and 15 is most likely shared between all Laurasiatheria species, indicating an ancestral gene loss." See supplementary material" |
10.1093/nargab/lqz012 |
| Phenotypic |
"Mutations in human CETP are associated with increased HDL cholesterol levels and reduced levels of the atherosclerosis-promoting LDL cholesterol (97,106)." |
10.1093/nargab/lqz012 |
| Other |
"Interestingly, many mammals have lost both PCSK9 and CETP." |
10.1093/nargab/lqz012 |