Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
CCL27 C-C motif chemokine ligand 27 ALP , ILC , CTAK , CTACK , PESKY , ESKINE , SCYA27 Homo sapiens 3 protein-coding CCL28, PF4V1, PF, PPBP, CXCL8, CXCL13, CXCL6, CXCL5 604833

Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

GeneOntology

Gene Loss events - CCL27 (18 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_KICLDM Lipotes vexillifer Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1007/s00251-019-01114-z
GL_M5RAPP Trichechus manatus Sirenia LOF (frameshift, premature stop, ss) Full No 10.1007/s00251-019-01114-z
GL_PDB6KU Manis javanica Pholidota LOF (frameshift, premature stop, ss) Full No 10.1007/s00251-019-01114-z
GL_PGGPLF Lagenorhynchus obliquidens Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1007/s00251-019-01114-z
GL_PYB16U Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1007/s00251-019-01114-z
GL_VZ15JI Sousa chinensis Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1007/s00251-019-01114-z
GL_XYMHGL Delphinapterus leucas Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1007/s00251-019-01114-z
GL_ZQZAKE Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full Cetacea 10.1007/s00251-019-01114-z