Ψ CCL27 - Orcinus orca
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_ZQZAKE | Orcinus orca | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_033437834.2 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "A conserved premature stop codon was found in Orcinus orca (orca) and Lagenorhynchus obliquidens (Pacific white-sided dolphin), as well as a non-conserved premature stop codon in L. vexillifer." | 10.1007/s00251-019-01114-z |
| Timing of Loss | "The conserved mutational pattern observed between Ccl27 Odontoceti and Mysticeti suggests that inactivation occurred in the Cetacea ancestor." | 10.1007/s00251-019-01114-z |
| Phenotypic | "Given the key role of CCL27 in the process of skin inflammation, we Ccl27 hypothesized that the coding sequence might be compromised in Cetacea as suggested by the overall skin inflammatory physiology observed in this lineage (Mouton and Botha 2012; Zabka and Romano 2003)." | 10.1007/s00251-019-01114-z |
Curator Observations
"A conserved premature stop codon was found in Orcinus orca (orca) and Lagenorhynchus obliquidens (Pacific white-sided dolphin), as well as a non-conserved premature stop codon in L. vexillifer."