Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CCL27 C-C motif chemokine ligand 27	ALP , ILC , CTAK , CTACK , PESKY , ESKINE , SCYA27	Homo sapiens	3	protein-coding	CCL28, PF4V1, PF, PPBP, CXCL8, CXCL13, CXCL6, CXCL5		604833

Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

GeneOntology

Function (1)

Go ID	Value	Evidence
0031728	enables CCR3 chemokine receptor binding	IPI

Component (3)

Go ID	Value	Evidence
0005576	is_active_in extracellular region	IBA
0005576	located_in extracellular region	TAS
0005615	located_in extracellular space	IEA

Process (5)

Go ID	Value	Evidence
0060326	involved_in cell chemotaxis	IEA
0007267	involved_in cell-cell signaling	TAS
0006935	involved_in chemotaxis	TAS
0006955	involved_in immune response	IEA
0007165	involved_in signal transduction	IEA

Gene Loss events - CCL27 (18 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_243WTL	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_5SDGQX	Manis pentadactyla	Pholidota	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00251-019-01114-z
GL_7S35RP	Rhinolophus sinicus	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00251-019-01114-z
GL_8BDLSO	Balaena mysticetus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_8LKTTF	Eschrichtius robustus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_8RVGR7	Hipposideros armiger	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00251-019-01114-z
GL_ANNFVS	Balaenoptera bonaerensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_E0PJF5	Neophocaena asiaeorientalis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_EFKDPN	Heterocephalus glaber	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00251-019-01114-z
GL_H0IJCE	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z